616.234.5000

Publications

Lempradl Laboratory

Publications

Lu TT, Heyne S, Dror E, Casas E, Leonhardt L, Boenke T, Yang CH, Sagar, Arrigoni L, Dalgaard K, Terperino R, Enders L, Selveraj M, Ruf M, Raja SJ, Xie H, Boenisch U, Orkin Sh, Lynn FC, Hoffman BG, Grün D, Vovouri T, Lempradl A, Pospisilik JA. 2018. The Polycomb-dependent epigenome controls b cell dysfunction, dedifferentiation and diabetes. Cell Metab 27(6):1294–1308. 

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Hendricks AE, Karaderi T, Lempradl A, …, Pospisilik JA, Rivadeneira F, Borecki IB, Deloukas P, Frayling TM, Lettre G, North KE, Lindgren CM, JN Hirschhorn, Loos RJF. 2018. Protein-altering variants associated with body mass index implicate 1 pathways that control energy intake and expenditure underpinning obesity. Nat Gen 50(1):26–41.

Theurich S, Tsaousidou E, Hanssen R, Lempradl A, Mauer J, Timper K, Schilbach K, Folz-Donahue K, Heilinger C, Sexl V, Pospisilik JA, Wunderlich FT, Brüning JC. 2017. IL-6/Stat3-dependent induction of a distinct, obesity-associated NK cell subpopulation deteriorates energy and glucose homeostasis. Cell Metab 26(1):171–184.

Dalgaard K, Landgraf K, Heyne S, Lempradl A, Longinotto J, Gossens K, Ruf M, Orthofer M, Strogantsev R, Selvaraj M, Casas E, Teperino R, Surani MA, Zvetkova I, Rimmington D, Tung L, Larder R, Yeo GSH, O’Rahilly S, Whitelaw E, Penninger JM, Jenuwein T, Cheung CL, Ferguson-Smith AC, Coll AP, Körner A, Pospisilik JA. 2016. Trim28 haploinsufficiency triggers bi-stable epigenetic obesity. Cell 164(3):353–364.

Lempradl A, Penninger JM, Pospisilik JA. 2015. Exploring the emerging complexity in transcriptional regulation of energy homeostasis. Nat Rev Genet 16(11):665–681.

Ost A*, Lempradl A*, Casas E, Weigert M, Tiko T, Deniz M, Pantano L, Boenisch U,Itskov PM, Stoeckius M, Ruf M, Rajewsky N, Reuter G, Iovino N, Ribeiro C, Alenius M, Heyne S, Vavouri T, Pospisilik JA. 2014. Paternal diet defines offspring chromatin state and intergenerational obesity. Cell 159(6):1352–1364.
*Co-first authors

Herzog VA*, Lempradl A*, Trupke J, Okulski H, Altmutter C, Ruge F, Boidol B, Kubicek S, Schmauss G, Aumayr K, Ruf M, Pospisilik A, Dimond A, Senergin HB, Vargas ML, Simon JA, Ringrose L. 2014. A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element. Nat Genet 46(9):973–981.
*Co-first authors

Teperino R, Lempradl A, Pospisilik JA. 2013. Bridging epigenomics and complex disease: the basics. Cell Mol Life Sci 70(9):1609–1621.

Lempradl A, Ringrose L. 2008. How does noncoding transcription regulate Hox genes? Bioessays 30(2):110–121.

Stampfl S, Lempradl A, Koehler G, Schroeder R. 2007. Monovalent ion dependence of neomycin B binding to an RNA aptamer characterized by spectroscopic methods. Chembiochem 8(10):1137–1145.

Lempradl A, Stampfl S, Koehler G. 2004. RNA-antibiotics interactions: A spectroscopic study of conformational changes upon binding. 48th Annual Meeting of the Biophysical Society, Baltimore Biophysical Journal 86(1):143A–143A part 2.